Over consumption of fructose: Fructose is an odd carbohydrate. It is really only usable by your liver as it requires GLUT5 for transport into cells. Fructose is essentially the opposite of refined starches as described above. Because of the special way in which fructose is metabolized it skips the rate-limiting step of PFK-1. Because of this it oxidizes in the liver incredibly quickly and tricks your liver in to thinking you have plenty of glucose even if you don?t. This affects the hepatic glucose sensor described previously. It causes increased GABA delivery to the PVN, thus slowing metabolism. It can induce hyperglycemia (our arch nemesis) by interactions with several systems. As stated, it reduces PVN firing so that means less thyroid, cortisol, and NE release. More importantly, fructose is non-insuligenic. Because of this it does not stimulate leptin or alpha-MSH production. So the LH in your brain never deciphers that the body is being fed. The third problem with fructose is that it fails to activate the portal vein glucose sensor, and thus it does not activate this essential glucose disposal mechanism. So in summation, fructose: slows metabolism, lowers leptin, fails to decrease hunger, and causes hyperglycemia. All in all too much fructose is just plain bad. Keep in mind a little fructose can be good, especially if you are an athlete. However for someone that is almost never glycogen depleted, fructose is detrimental and only does harm (36). Zgoraj v tekstu so opisani mehanizmi, preko katerih fruktoza negativno učinkuje na izgubo maščobe, ker pride zniža padec presnove, znižanja ravni leptina, pravtako pa ne vpliva na uravnavanje lakote ter znižuje senzitivnost na inzulin na celicah. Torej, če ste na dieti, čim manj fruktoze. Če se želite le prehranjevati zdravo, pa zmerno v obliki nekaj sadežev na dan. |
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