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Bismuth
and its salts can cause kidney damage, although the degree of such
damage is usually mild. Large doses can be fatal. Industrially it is
considered one of the less toxic of the heavy metals. Serious and
sometimes fatal poisoning may occur from the injection of large doses
into closed cavities and from extensive application to burns (in form of
soluble bismuth compounds). It is stated that the administration of
bismuth should be stopped when gingivitis appears, for otherwise serious
ulceration stomatitis is likely to result. Other toxic results may
develop, such as vague feeling of bodily discomfort, presence of albumin
or other protein substance in the urine, diarrhea, skin reactions and
sometimes serious exodermatitis.
Routes
of entry: Inhalation, skin and ingestion.
Acute
effects: Inhalation: POISON. May be a nuisance dust causing
respiratory irritation. May cause foul breath, metallic taste and
gingivitis. Ingestion: POISON. May cause nausea, loss of appetite
and weight, malaise, albuminuria, diarrhea, skin reactions,
stomatitis, headache, fever, sleeplessness,
depression, rheumatic pain and a black line may form on gums in the
mouth due to deposition of bismuth
sulphide. Skin: May cause irritation.
Eyes: May cause irritation.
Chronic
effects: Inhalation: May affect the function of the liver and the
kidneys.
Ingestion:
May affect the function of the liver and the kidneys. May cause anemia,
black line may form on gums and ulcerative stomatitis. Skin: May cause
dermatitis. Eyes: No chronic health effects recorded.
Medical
conditions generally aggravated by the exposure:
Pre-existing skin and respiratory disorders.
Bismuth is not considered a human carcinogen.
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